Drug interactions
Efavirenz + Saxagliptin
Severity: Minor
Efavirenz and Saxagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz, a CYP3A4 inducer, may reduce saxagliptin and its active metabolite exposure. A clinically important loss of glucose-lowering effect is not expected from this interaction.
What this interaction means in plain words
Efavirenz and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Efavirenz belongs to Anti Virals; Saxagliptin belongs to Endocrine.
Why it happens
Efavirenz induces CYP3A4/5, which metabolizes saxagliptin to its active metabolite and clears the parent drug.
What to do
No dose change is routinely required. Monitor glycemic control when efavirenz is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Efavirenz with Saxagliptin?
MediHelp rates the interaction as minor. Efavirenz and Saxagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Efavirenz, a CYP3A4 inducer, may reduce saxagliptin and its active metabolite exposure. A clinically important loss of glucose-lowering effect is not expected from this interaction.
How serious is the interaction between Efavirenz and Saxagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely required. Monitor glycemic control when efavirenz is started or stopped.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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