Drug interactions
Efavirenz + Tipranavir
Severity: Moderate
Efavirenz and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz and ritonavir-boosted tipranavir affect each other's CYP3A4 metabolism in opposite directions, so net exposure of either drug can change unpredictably. Both are antiretrovirals that can also be linked with immune reconstitution inflammatory syndrome when therapy is started.
What this interaction means in plain words
Efavirenz and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Tipranavir belongs to Anti Virals.
Why it happens
Mixed CYP3A4 induction by efavirenz and inhibition/induction by tipranavir/ritonavir alters concentrations of both drugs.
What to do
If combined, monitor HIV viral load and tipranavir trough levels where available, plus liver enzymes and lipids. Watch for inflammatory symptoms in the first weeks of therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Efavirenz with Tipranavir?
MediHelp rates the interaction as moderate. Efavirenz and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz and ritonavir-boosted tipranavir affect each other's CYP3A4 metabolism in opposite directions, so net exposure of either drug can change unpredictably. Both are antiretrovirals that can also be linked with immune reconstitution inflammatory syndrome when therapy is started.
How serious is the interaction between Efavirenz and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If combined, monitor HIV viral load and tipranavir trough levels where available, plus liver enzymes and lipids. Watch for inflammatory symptoms in the first weeks of therapy.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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