Drug interactions
Rifampicin + Tolebrutinib
Severity: Major
Rifampicin and Tolebrutinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin is a potent inducer of CYP3A and CYP2C8 and markedly reduces tolebrutinib exposure. Therapeutic benefit may be lost.
What this interaction means in plain words
Rifampicin and Tolebrutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Rifampicin belongs to Anti Bacterial; Tolebrutinib belongs to Central Nervous System.
Why it happens
Potent induction of CYP3A4 and CYP2C8 increases tolebrutinib metabolism.
What to do
Avoid prolonged coadministration. For courses under two weeks, tolebrutinib may be continued; otherwise consider alternative therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tolebrutinib
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Rifampicin with Tolebrutinib?
MediHelp rates the interaction as major. Rifampicin and Tolebrutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifampicin is a potent inducer of CYP3A and CYP2C8 and markedly reduces tolebrutinib exposure. Therapeutic benefit may be lost.
How serious is the interaction between Rifampicin and Tolebrutinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged coadministration. For courses under two weeks, tolebrutinib may be continued; otherwise consider alternative therapy.
What other medicines interact with Tolebrutinib?
MediHelp also lists interactions of Tolebrutinib with, for example, Carbamazepine, Deferasirox, Efavirenz. The full list is on the Tolebrutinib page.
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