Drug interactions
Efavirenz + Vorinostat
Severity: Moderate
Efavirenz and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT prolongation, so combined use may add to arrhythmia risk. The risk is greater with electrolyte disturbance or other QT-prolonging drugs.
What this interaction means in plain words
Efavirenz and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Vorinostat belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Monitor ECG and correct potassium and magnesium before and during therapy. Avoid adding other QT-prolonging agents.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Efavirenz with Vorinostat?
MediHelp rates the interaction as moderate. Efavirenz and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT prolongation, so combined use may add to arrhythmia risk. The risk is greater with electrolyte disturbance or other QT-prolonging drugs.
How serious is the interaction between Efavirenz and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and correct potassium and magnesium before and during therapy. Avoid adding other QT-prolonging agents.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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