Drug interactions
Efgartigimod alfa + Sarilumab
Severity: Moderate
Efgartigimod alfa and Sarilumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efgartigimod blocks the neonatal Fc receptor, which normally recycles IgG. Sarilumab is an IgG1 antibody, so its exposure and effectiveness may fall.
What this interaction means in plain words
Efgartigimod alfa and Sarilumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efgartigimod alfa belongs to Miscellaneous; Sarilumab belongs to Musculoskeletal.
Why it happens
FcRn blockade by efgartigimod increases the catabolism of IgG-based drugs such as sarilumab.
What to do
Monitor for loss of sarilumab effect on disease activity. If sarilumab is essential long term, consider alternative therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sarilumab
Other interactions of Efgartigimod alfa
- Adalimumab + Efgartigimod alfa Moderate
- Ado-trastuzumab + Efgartigimod alfa Moderate
- Basiliximab + Efgartigimod alfa Moderate
- Bevacizumab + Efgartigimod alfa Moderate
- Brentuximab + Efgartigimod alfa Moderate
- Denosumab + Efgartigimod alfa Moderate
Frequently asked questions
Can I take Efgartigimod alfa with Sarilumab?
MediHelp rates the interaction as moderate. Efgartigimod alfa and Sarilumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efgartigimod blocks the neonatal Fc receptor, which normally recycles IgG. Sarilumab is an IgG1 antibody, so its exposure and effectiveness may fall.
How serious is the interaction between Efgartigimod alfa and Sarilumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of sarilumab effect on disease activity. If sarilumab is essential long term, consider alternative therapy.
What other medicines interact with Sarilumab?
MediHelp also lists interactions of Sarilumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Dengue vaccine. The full list is on the Sarilumab page.
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