Drug interactions
Efgartigimod / hyaluronidase sc + Golimumab
Severity: Moderate
Efgartigimod / hyaluronidase sc and Golimumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efgartigimod blocks the neonatal Fc receptor, which normally recycles IgG-based drugs. Golimumab is a human IgG1 antibody, so its exposure and efficacy may be reduced.
What this interaction means in plain words
Efgartigimod / hyaluronidase sc and Golimumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
FcRn blockade by efgartigimod increases catabolism of IgG, including IgG-based therapeutic antibodies.
What to do
Monitor for loss of golimumab effect and consider alternative therapy if long-term golimumab is essential. Consider timing doses toward the end of efgartigimod cycles.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Golimumab
- Bcg vaccine live + Golimumab Contraindicated
- Etanercept + Golimumab Contraindicated
- Golimumab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Golimumab + Measles mumps and rubella vaccine Contraindicated
- Golimumab + Measles mumps and rubella vaccine live Contraindicated
- Golimumab + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Efgartigimod / hyaluronidase sc with Golimumab?
MediHelp rates the interaction as moderate. Efgartigimod / hyaluronidase sc and Golimumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efgartigimod blocks the neonatal Fc receptor, which normally recycles IgG-based drugs. Golimumab is a human IgG1 antibody, so its exposure and efficacy may be reduced.
How serious is the interaction between Efgartigimod / hyaluronidase sc and Golimumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of golimumab effect and consider alternative therapy if long-term golimumab is essential. Consider timing doses toward the end of efgartigimod cycles.
What other medicines interact with Golimumab?
MediHelp also lists interactions of Golimumab with, for example, Bcg vaccine live, Etanercept, Influenza virus vaccine quadrivalent intranasal. The full list is on the Golimumab page.
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