Drug interactions
Efgartigimod / hyaluronidase sc + Infliximab
Severity: Moderate
Efgartigimod / hyaluronidase sc and Infliximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efgartigimod blocks the neonatal Fc receptor and accelerates IgG catabolism, which may lower infliximab concentrations, an IgG1 antibody. This could reduce infliximab efficacy.
What this interaction means in plain words
Efgartigimod / hyaluronidase sc and Infliximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
FcRn blockade reduces IgG recycling and shortens infliximab half-life.
What to do
Monitor for loss of infliximab response and consider checking trough levels. If infliximab is essential long term, consider alternatives to efgartigimod.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps and rubella vaccine live Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Measles vaccine Contraindicated
Frequently asked questions
Can I take Efgartigimod / hyaluronidase sc with Infliximab?
MediHelp rates the interaction as moderate. Efgartigimod / hyaluronidase sc and Infliximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efgartigimod blocks the neonatal Fc receptor and accelerates IgG catabolism, which may lower infliximab concentrations, an IgG1 antibody. This could reduce infliximab efficacy.
How serious is the interaction between Efgartigimod / hyaluronidase sc and Infliximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of infliximab response and consider checking trough levels. If infliximab is essential long term, consider alternatives to efgartigimod.
What other medicines interact with Infliximab?
MediHelp also lists interactions of Infliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Infliximab page.
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