Drug interactions
Elacestrant + Imatinib
Severity: Moderate
Elacestrant and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib may increase elacestrant exposure by inhibiting CYP3A4. This could increase elacestrant adverse effects such as nausea, dyslipidemia and musculoskeletal pain.
What this interaction means in plain words
Elacestrant and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elacestrant belongs to Oncology; Imatinib belongs to Oncology.
Why it happens
Imatinib inhibits CYP3A4-mediated metabolism of elacestrant.
What to do
Avoid coadministration where possible and use an alternative to imatinib; if the combination is necessary, monitor for elacestrant adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Elacestrant
Frequently asked questions
Can I take Elacestrant with Imatinib?
MediHelp rates the interaction as moderate. Elacestrant and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib may increase elacestrant exposure by inhibiting CYP3A4. This could increase elacestrant adverse effects such as nausea, dyslipidemia and musculoskeletal pain.
How serious is the interaction between Elacestrant and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration where possible and use an alternative to imatinib; if the combination is necessary, monitor for elacestrant adverse effects.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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