Drug interactions
Elacestrant + Topotecan
Severity: Moderate
Elacestrant and Topotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elacestrant inhibits BCRP, a transporter that limits intestinal absorption and promotes elimination of topotecan. Exposure to topotecan, particularly oral topotecan, may increase, with greater myelosuppression and gastrointestinal toxicity.
What this interaction means in plain words
Elacestrant and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elacestrant belongs to Oncology; Topotecan belongs to Oncology.
Why it happens
Inhibition of BCRP efflux transport by elacestrant increases topotecan absorption and reduces its clearance.
What to do
Monitor blood counts and gastrointestinal toxicity, and consider reducing the topotecan dose if toxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporine + Topotecan Major
- Cyclosporin + Topotecan Major
Other interactions of Elacestrant
Frequently asked questions
Can I take Elacestrant with Topotecan?
MediHelp rates the interaction as moderate. Elacestrant and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elacestrant inhibits BCRP, a transporter that limits intestinal absorption and promotes elimination of topotecan. Exposure to topotecan, particularly oral topotecan, may increase, with greater myelosuppression and gastrointestinal toxicity.
How serious is the interaction between Elacestrant and Topotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and gastrointestinal toxicity, and consider reducing the topotecan dose if toxicity emerges.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
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