Drug interactions
Elbasvir / grazoprevir + Enzalutamide
Severity: Contraindicated
Elbasvir / grazoprevir and Enzalutamide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A inducers reduce plasma concentrations of elbasvir and grazoprevir, and labeling contraindicates their use. Lower levels may lead to hepatitis C treatment failure and resistance.
What this interaction means in plain words
Elbasvir / grazoprevir and Enzalutamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Enzalutamide induces CYP3A4 (and P-gp), increasing elimination of elbasvir and grazoprevir.
What to do
Do not use together; choose a different HCV regimen or defer therapy until enzalutamide is no longer needed. Check SVR at the appropriate time if exposure occurred.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Enzalutamide + Lonafarnib Contraindicated
Frequently asked questions
Can I take Elbasvir / grazoprevir with Enzalutamide?
MediHelp rates the interaction as contraindicated. Elbasvir / grazoprevir and Enzalutamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Strong CYP3A inducers reduce plasma concentrations of elbasvir and grazoprevir, and labeling contraindicates their use. Lower levels may lead to hepatitis C treatment failure and resistance.
How serious is the interaction between Elbasvir / grazoprevir and Enzalutamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose a different HCV regimen or defer therapy until enzalutamide is no longer needed. Check SVR at the appropriate time if exposure occurred.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Ensitrelvir, Fostemsavir. The full list is on the Enzalutamide page.
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