Drug interactions
Ensitrelvir + Enzalutamide
Severity: Contraindicated
Ensitrelvir and Enzalutamide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A inducer and is expected to considerably lower ensitrelvir exposure. Antiviral efficacy may be lost.
What this interaction means in plain words
Ensitrelvir and Enzalutamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ensitrelvir belongs to Anti Virals; Enzalutamide belongs to Endocrine.
Why it happens
Enzalutamide induces CYP3A, accelerating ensitrelvir metabolism.
What to do
Do not co-administer; use an alternative COVID-19 agent not dependent on CYP3A exposure.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ensitrelvir
- Apalutamide + Ensitrelvir Contraindicated
- Carbamazepine + Ensitrelvir Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Ensitrelvir + Ivabradine Contraindicated
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Enzalutamide + Lonafarnib Contraindicated
Frequently asked questions
Can I take Ensitrelvir with Enzalutamide?
MediHelp rates the interaction as contraindicated. Ensitrelvir and Enzalutamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Enzalutamide is a strong CYP3A inducer and is expected to considerably lower ensitrelvir exposure. Antiviral efficacy may be lost.
How serious is the interaction between Ensitrelvir and Enzalutamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use an alternative COVID-19 agent not dependent on CYP3A exposure.
What other medicines interact with Ensitrelvir?
MediHelp also lists interactions of Ensitrelvir with, for example, Apalutamide, Carbamazepine, Colchicine. The full list is on the Ensitrelvir page.
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