Drug interactions
Eletriptan + Elvitegravir / cobicistat / emtricitabine / tenofovir df
Severity: Contraindicated
Eletriptan and Elvitegravir / cobicistat / emtricitabine / tenofovir df: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The cobicistat component strongly inhibits CYP3A4 and is expected to markedly raise eletriptan exposure. This increases the risk of vasospasm and hypertensive cardiovascular events.
What this interaction means in plain words
Eletriptan and Elvitegravir / cobicistat / emtricitabine / tenofovir df are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Cobicistat inhibits CYP3A4, reducing eletriptan metabolism.
What to do
Avoid eletriptan while on a cobicistat-boosted regimen and for 72 hours after a strong CYP3A4 inhibitor. Use another triptan with less CYP3A4 dependence.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates the interaction as contraindicated. Eletriptan and Elvitegravir / cobicistat / emtricitabine / tenofovir df are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The cobicistat component strongly inhibits CYP3A4 and is expected to markedly raise eletriptan exposure. This increases the risk of vasospasm and hypertensive cardiovascular events.
How serious is the interaction between Eletriptan and Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid eletriptan while on a cobicistat-boosted regimen and for 72 hours after a strong CYP3A4 inhibitor. Use another triptan with less CYP3A4 dependence.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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