Drug interactions
Eletriptan + Escitalopram
Severity: Moderate
Eletriptan and Escitalopram: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs enhance serotonergic activity, and combined use has been associated with reports of serotonin syndrome, though the absolute risk appears low. Features include agitation, tremor, sweating, hyperreflexia, diarrhea and hyperthermia.
What this interaction means in plain words
Eletriptan and Escitalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Escitalopram belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from SSRI reuptake inhibition and 5-HT1B/1D agonism.
What to do
The combination can be used when clinically needed; counsel patients on symptoms of serotonin syndrome and monitor after initiation or dose increases. Stop both agents and give supportive care if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Escitalopram?
MediHelp rates the interaction as moderate. Eletriptan and Escitalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs enhance serotonergic activity, and combined use has been associated with reports of serotonin syndrome, though the absolute risk appears low. Features include agitation, tremor, sweating, hyperreflexia, diarrhea and hyperthermia.
How serious is the interaction between Eletriptan and Escitalopram?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: The combination can be used when clinically needed; counsel patients on symptoms of serotonin syndrome and monitor after initiation or dose increases. Stop both agents and give supportive care if toxicity develops.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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