Drug interactions
Eletriptan + Fexinidazole
Severity: Major
Eletriptan and Fexinidazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eletriptan is a sensitive CYP3A4 substrate, and its exposure rises markedly with strong inhibitors. Fexinidazole has been reported to inhibit CYP3A4, so eletriptan levels could rise and increase adverse effects such as hypertension and vasoconstriction. Eletriptan labeling contraindicates use with strong CYP3A4 inhibitors.
What this interaction means in plain words
Eletriptan and Fexinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of CYP3A4-mediated eletriptan metabolism reduces its clearance.
What to do
Avoid eletriptan during fexinidazole therapy and use a triptan that does not depend on CYP3A4, such as sumatriptan or rizatriptan. If unavoidable, monitor blood pressure and adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Fexinidazole?
MediHelp rates the interaction as major. Eletriptan and Fexinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eletriptan is a sensitive CYP3A4 substrate, and its exposure rises markedly with strong inhibitors. Fexinidazole has been reported to inhibit CYP3A4, so eletriptan levels could rise and increase adverse effects such as hypertension and vasoconstriction. Eletriptan labeling contraindicates use with strong CYP3A4 inhibitors.
How serious is the interaction between Eletriptan and Fexinidazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid eletriptan during fexinidazole therapy and use a triptan that does not depend on CYP3A4, such as sumatriptan or rizatriptan. If unavoidable, monitor blood pressure and adverse effects.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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