Drug interactions
Eletriptan + Fosphenytoin
Severity: Moderate
Eletriptan and Fosphenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosphenytoin is converted to phenytoin, an inducer of CYP3A4, which may lower eletriptan concentrations. Reduced exposure could lead to less effective migraine relief.
What this interaction means in plain words
Eletriptan and Fosphenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Fosphenytoin belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by phenytoin increases eletriptan metabolism.
What to do
Watch for reduced headache response. If efficacy is inadequate, consider a triptan less dependent on CYP3A4 metabolism.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Other interactions of Fosphenytoin
- Dronedarone + Fosphenytoin Contraindicated
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
- Fosphenytoin + Lurasidone Contraindicated
- Fosphenytoin + Ranolazine Contraindicated
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Eletriptan with Fosphenytoin?
MediHelp rates the interaction as moderate. Eletriptan and Fosphenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosphenytoin is converted to phenytoin, an inducer of CYP3A4, which may lower eletriptan concentrations. Reduced exposure could lead to less effective migraine relief.
How serious is the interaction between Eletriptan and Fosphenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for reduced headache response. If efficacy is inadequate, consider a triptan less dependent on CYP3A4 metabolism.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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