Drug interactions
Eletriptan + Isoniazid
Severity: Moderate
Eletriptan and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eletriptan is a sensitive CYP3A4 substrate and isoniazid may weakly inhibit this enzyme, possibly raising triptan exposure. Isoniazid's weak MAO inhibition adds a theoretical serotonergic effect. Clinically significant reactions are uncommon.
What this interaction means in plain words
Eletriptan and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Isoniazid belongs to Anti Bacterial.
Why it happens
Weak CYP3A4 inhibition and MAO inhibition by isoniazid may increase eletriptan exposure and serotonergic effects.
What to do
Use the lowest effective eletriptan dose and watch for serotonin toxicity or elevated blood pressure. Consider an alternative triptan if symptoms arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Isoniazid?
MediHelp rates the interaction as moderate. Eletriptan and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eletriptan is a sensitive CYP3A4 substrate and isoniazid may weakly inhibit this enzyme, possibly raising triptan exposure. Isoniazid's weak MAO inhibition adds a theoretical serotonergic effect. Clinically significant reactions are uncommon.
How serious is the interaction between Eletriptan and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective eletriptan dose and watch for serotonin toxicity or elevated blood pressure. Consider an alternative triptan if symptoms arise.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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