Drug interactions
Eletriptan + L-tryptophan
Severity: Moderate
Eletriptan and L-tryptophan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
L-tryptophan is a serotonin precursor, and with a triptan it may theoretically add to serotonergic effects. Serotonin syndrome is possible but uncommon.
What this interaction means in plain words
Eletriptan and L-tryptophan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Increased serotonin synthesis from tryptophan adds to 5-HT receptor agonism from eletriptan.
What to do
Monitor for serotonin syndrome features such as agitation, tremor, and hyperthermia. Reduce or stop tryptophan if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with L-tryptophan?
MediHelp rates the interaction as moderate. Eletriptan and L-tryptophan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. L-tryptophan is a serotonin precursor, and with a triptan it may theoretically add to serotonergic effects. Serotonin syndrome is possible but uncommon.
How serious is the interaction between Eletriptan and L-tryptophan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome features such as agitation, tremor, and hyperthermia. Reduce or stop tryptophan if symptoms develop.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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