Drug interactions
Eletriptan + Lithium
Severity: Minor
Eletriptan and Lithium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lithium may enhance serotonergic neurotransmission and eletriptan is a 5-HT1B/1D agonist, so serotonin syndrome is a theoretical concern. Reports are rare and the risk appears low at usual doses.
What this interaction means in plain words
Eletriptan and Lithium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eletriptan belongs to Central Nervous System; Lithium belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects at serotonin receptors; no established pharmacokinetic interaction.
What to do
Use at standard doses and counsel the patient to seek help for agitation, tremor, sweating, diarrhea or fever. Avoid exceeding the maximum triptan dosing.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Lithium?
MediHelp rates the interaction as minor. Eletriptan and Lithium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lithium may enhance serotonergic neurotransmission and eletriptan is a 5-HT1B/1D agonist, so serotonin syndrome is a theoretical concern. Reports are rare and the risk appears low at usual doses.
How serious is the interaction between Eletriptan and Lithium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use at standard doses and counsel the patient to seek help for agitation, tremor, sweating, diarrhea or fever. Avoid exceeding the maximum triptan dosing.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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