Drug interactions
Eletriptan + Lofepramine
Severity: Minor
Eletriptan and Lofepramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic antidepressant with serotonin reuptake inhibition, so combination with a triptan could theoretically contribute to serotonin syndrome. Its effect on serotonin is weaker than some other tricyclics.
What this interaction means in plain words
Eletriptan and Lofepramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive serotonergic activity from reuptake inhibition and triptan receptor agonism.
What to do
Monitor for symptoms of serotonin toxicity when starting or increasing doses and counsel the patient on warning signs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eletriptan and Lofepramine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Lofepramine?
MediHelp rates the interaction as minor. Eletriptan and Lofepramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lofepramine is a tricyclic antidepressant with serotonin reuptake inhibition, so combination with a triptan could theoretically contribute to serotonin syndrome. Its effect on serotonin is weaker than some other tricyclics.
How serious is the interaction between Eletriptan and Lofepramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for symptoms of serotonin toxicity when starting or increasing doses and counsel the patient on warning signs.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
