Drug interactions
Eletriptan + Lorcaserin
Severity: Moderate
Eletriptan and Lorcaserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs raise serotonergic activity, so combining them could lead to serotonin syndrome. Reported cases are rare, but labeling cautions about the combination. Lorcaserin has been withdrawn from the US market.
What this interaction means in plain words
Eletriptan and Lorcaserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects from 5-HT2C agonism by lorcaserin and 5-HT1B/1D agonism by the triptan.
What to do
If used together, monitor for serotonin syndrome after dose changes. Stop one agent if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eletriptan and Lorcaserin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Lorcaserin?
MediHelp rates the interaction as moderate. Eletriptan and Lorcaserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs raise serotonergic activity, so combining them could lead to serotonin syndrome. Reported cases are rare, but labeling cautions about the combination. Lorcaserin has been withdrawn from the US market.
How serious is the interaction between Eletriptan and Lorcaserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If used together, monitor for serotonin syndrome after dose changes. Stop one agent if symptoms occur.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
