Drug interactions
Eletriptan + Nefazodone
Severity: Contraindicated
Eletriptan and Nefazodone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a potent CYP3A4 inhibitor and can markedly increase eletriptan exposure. This raises the risk of vasospasm, hypertension and other triptan toxicity.
What this interaction means in plain words
Eletriptan and Nefazodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Inhibition of CYP3A4 metabolism of eletriptan.
What to do
Avoid eletriptan within 72 hours of nefazodone. Use a triptan not dependent on CYP3A4 if needed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Nefazodone?
MediHelp rates the interaction as contraindicated. Eletriptan and Nefazodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nefazodone is a potent CYP3A4 inhibitor and can markedly increase eletriptan exposure. This raises the risk of vasospasm, hypertension and other triptan toxicity.
How serious is the interaction between Eletriptan and Nefazodone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid eletriptan within 72 hours of nefazodone. Use a triptan not dependent on CYP3A4 if needed.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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