Drug interactions
Eletriptan + Olanzapine
Severity: Moderate
Eletriptan and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triptans have serotonergic activity and antipsychotics with 5-HT2A antagonism are occasionally linked to serotonin toxicity or neuroleptic malignant syndrome when combined with serotonergic agents. The risk is thought to be low and based on limited case reports, but the outcomes could be serious.
What this interaction means in plain words
Eletriptan and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Olanzapine belongs to Central Nervous System.
Why it happens
Possible additive serotonergic activity; the mechanism is not firmly established.
What to do
Educate the patient to report agitation, tremor, fever, sweating or rigidity after dosing. Seek urgent review if symptoms appear and stop the triptan.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Olanzapine?
MediHelp rates the interaction as moderate. Eletriptan and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triptans have serotonergic activity and antipsychotics with 5-HT2A antagonism are occasionally linked to serotonin toxicity or neuroleptic malignant syndrome when combined with serotonergic agents. The risk is thought to be low and based on limited case reports, but the outcomes could be serious.
How serious is the interaction between Eletriptan and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Educate the patient to report agitation, tremor, fever, sweating or rigidity after dosing. Seek urgent review if symptoms appear and stop the triptan.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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