Drug interactions
Eletriptan + Phenobarbital
Severity: Moderate
Eletriptan and Phenobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital is an established CYP3A4 inducer and may reduce eletriptan exposure. Migraine treatment may be less effective.
What this interaction means in plain words
Eletriptan and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 by phenobarbital increases eletriptan clearance.
What to do
Monitor for reduced efficacy and consider switching to a triptan not metabolized by CYP3A4.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Phenobarbital?
MediHelp rates the interaction as moderate. Eletriptan and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbital is an established CYP3A4 inducer and may reduce eletriptan exposure. Migraine treatment may be less effective.
How serious is the interaction between Eletriptan and Phenobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced efficacy and consider switching to a triptan not metabolized by CYP3A4.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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