Drug interactions
Eletriptan + Pimozide
Severity: Minor
Eletriptan and Pimozide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eletriptan is metabolized mainly by CYP3A4, and pimozide is not a significant CYP3A4 inhibitor, so a pharmacokinetic interaction is unlikely. A pharmacodynamic serotonin syndrome or neuroleptic malignant syndrome risk is theoretical and poorly supported.
What this interaction means in plain words
Eletriptan and Pimozide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eletriptan belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Why it happens
Theoretical serotonergic and dopaminergic pharmacodynamic overlap; no established mechanism.
What to do
No routine change is needed. Educate the patient to report agitation, fever, rigidity or autonomic instability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Pimozide?
MediHelp rates the interaction as minor. Eletriptan and Pimozide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eletriptan is metabolized mainly by CYP3A4, and pimozide is not a significant CYP3A4 inhibitor, so a pharmacokinetic interaction is unlikely. A pharmacodynamic serotonin syndrome or neuroleptic malignant syndrome risk is theoretical and poorly supported.
How serious is the interaction between Eletriptan and Pimozide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Educate the patient to report agitation, fever, rigidity or autonomic instability.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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