Drug interactions
Eletriptan + Protriptyline
Severity: Moderate
Eletriptan and Protriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protriptyline, a tricyclic antidepressant, may add to triptan serotonergic effects and theoretically cause serotonin syndrome. Reports are rare.
What this interaction means in plain words
Eletriptan and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects from reuptake inhibition and triptan 5-HT1 agonism.
What to do
Monitor for serotonin toxicity symptoms, especially after dose changes, and counsel the patient to report them.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Protriptyline?
MediHelp rates the interaction as moderate. Eletriptan and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protriptyline, a tricyclic antidepressant, may add to triptan serotonergic effects and theoretically cause serotonin syndrome. Reports are rare.
How serious is the interaction between Eletriptan and Protriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin toxicity symptoms, especially after dose changes, and counsel the patient to report them.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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