Drug interactions
Eletriptan + Quinupristin / dalfopristin
Severity: Moderate
Eletriptan and Quinupristin / dalfopristin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and may raise eletriptan exposure. Higher eletriptan levels could increase triptan adverse effects such as vasoconstriction, hypertension and chest symptoms.
What this interaction means in plain words
Eletriptan and Quinupristin / dalfopristin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated eletriptan metabolism by quinupristin/dalfopristin.
What to do
Monitor for triptan adverse effects such as increased blood pressure and chest tightness. Consider an alternative antibiotic or a non-CYP3A4-dependent triptan if problems occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Quinupristin / dalfopristin?
MediHelp rates the interaction as moderate. Eletriptan and Quinupristin / dalfopristin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinupristin/dalfopristin inhibits CYP3A4 and may raise eletriptan exposure. Higher eletriptan levels could increase triptan adverse effects such as vasoconstriction, hypertension and chest symptoms.
How serious is the interaction between Eletriptan and Quinupristin / dalfopristin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for triptan adverse effects such as increased blood pressure and chest tightness. Consider an alternative antibiotic or a non-CYP3A4-dependent triptan if problems occur.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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