Drug interactions
Eletriptan + Rifampin
Severity: Moderate
Eletriptan and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin is a strong inducer of CYP3A4 and P-gp, and eletriptan is cleared mainly by CYP3A4. Eletriptan exposure may fall, which may lead to reduced migraine relief. The effect is a loss of efficacy rather than toxicity.
What this interaction means in plain words
Eletriptan and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 (and P-gp) by rifampin increases eletriptan metabolism and lowers its concentrations.
What to do
Monitor for lack of response to eletriptan. Consider an alternative triptan not dependent on CYP3A4 if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Rifampin?
MediHelp rates the interaction as moderate. Eletriptan and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin is a strong inducer of CYP3A4 and P-gp, and eletriptan is cleared mainly by CYP3A4. Eletriptan exposure may fall, which may lead to reduced migraine relief. The effect is a loss of efficacy rather than toxicity.
How serious is the interaction between Eletriptan and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for lack of response to eletriptan. Consider an alternative triptan not dependent on CYP3A4 if efficacy is lost.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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