Drug interactions
Eletriptan + Same
Severity: Moderate
Eletriptan and Same: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
S-adenosylmethionine (SAMe) has serotonergic activity and combined use with a triptan may add to serotonergic stimulation. Serotonin syndrome is a theoretical concern, with evidence limited mostly to case-level and mechanistic data.
What this interaction means in plain words
Eletriptan and Same can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects; SAMe may increase brain serotonin turnover.
What to do
Counsel the patient to report agitation, tremor, sweating, diarrhea or fever. Consider avoiding SAMe in patients using triptans frequently.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Same?
MediHelp rates the interaction as moderate. Eletriptan and Same can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. S-adenosylmethionine (SAMe) has serotonergic activity and combined use with a triptan may add to serotonergic stimulation. Serotonin syndrome is a theoretical concern, with evidence limited mostly to case-level and mechanistic data.
How serious is the interaction between Eletriptan and Same?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report agitation, tremor, sweating, diarrhea or fever. Consider avoiding SAMe in patients using triptans frequently.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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