Drug interactions
Eletriptan + Selegiline transdermal
Severity: Major
Eletriptan and Selegiline transdermal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline is a monoamine oxidase inhibitor and transdermal use gives systemic MAO inhibition, which can potentiate serotonergic drugs. Combined with a triptan it may raise the risk of serotonin syndrome.
What this interaction means in plain words
Eletriptan and Selegiline transdermal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
MAO inhibition combined with triptan 5-HT1B/1D agonism gives additive serotonergic effects.
What to do
Avoid the combination where possible and choose another migraine treatment. If used, monitor closely for serotonin syndrome and hypertensive reactions.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Selegiline transdermal?
MediHelp rates the interaction as major. Eletriptan and Selegiline transdermal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Selegiline is a monoamine oxidase inhibitor and transdermal use gives systemic MAO inhibition, which can potentiate serotonergic drugs. Combined with a triptan it may raise the risk of serotonin syndrome.
How serious is the interaction between Eletriptan and Selegiline transdermal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose another migraine treatment. If used, monitor closely for serotonin syndrome and hypertensive reactions.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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