Drug interactions
Eletriptan + Sufentanil sl
Severity: Moderate
Eletriptan and Sufentanil sl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have serotonergic activity, so use together carries a risk of serotonin syndrome. Symptoms include agitation, tremor, hyperreflexia, sweating and hyperthermia.
What this interaction means in plain words
Eletriptan and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects of the opioid and the 5-HT1B/1D agonist.
What to do
Observe for features of serotonin toxicity, especially at initiation or dose increases. Stop both agents and treat supportively if it develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Sufentanil sl?
MediHelp rates the interaction as moderate. Eletriptan and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have serotonergic activity, so use together carries a risk of serotonin syndrome. Symptoms include agitation, tremor, hyperreflexia, sweating and hyperthermia.
How serious is the interaction between Eletriptan and Sufentanil sl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Observe for features of serotonin toxicity, especially at initiation or dose increases. Stop both agents and treat supportively if it develops.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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