Drug interactions
Eletriptan + Sumatriptan intranasal
Severity: Contraindicated
Eletriptan and Sumatriptan intranasal: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two 5-HT1B/1D agonists taken close together produce additive vasoconstriction, with a risk of coronary or peripheral vasospasm and blood pressure elevation. Combining them offers no proven added benefit.
What this interaction means in plain words
Eletriptan and Sumatriptan intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive serotonin 5-HT1B/1D receptor agonism causing vasoconstriction.
What to do
Do not use two triptans within 24 hours of each other. If one fails, wait at least 24 hours before using the second.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Sumatriptan intranasal?
MediHelp rates the interaction as contraindicated. Eletriptan and Sumatriptan intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Two 5-HT1B/1D agonists taken close together produce additive vasoconstriction, with a risk of coronary or peripheral vasospasm and blood pressure elevation. Combining them offers no proven added benefit.
How serious is the interaction between Eletriptan and Sumatriptan intranasal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use two triptans within 24 hours of each other. If one fails, wait at least 24 hours before using the second.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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