Drug interactions
Eletriptan + Thiothixene
Severity: Moderate
Eletriptan and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a triptan with an antipsychotic has been associated with serotonin syndrome and possibly neuroleptic malignant syndrome, although the risk is thought to be low. Both syndromes can present with altered mental status, rigidity and autonomic instability.
What this interaction means in plain words
Eletriptan and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic and dopaminergic effects; thiothixene blocks dopamine and 5-HT2 receptors while the triptan stimulates 5-HT1B/1D receptors.
What to do
Monitor for mental status change, hyperthermia, rigidity and autonomic instability. Discontinue the agents if features of either syndrome appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Thiothixene?
MediHelp rates the interaction as moderate. Eletriptan and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a triptan with an antipsychotic has been associated with serotonin syndrome and possibly neuroleptic malignant syndrome, although the risk is thought to be low. Both syndromes can present with altered mental status, rigidity and autonomic instability.
How serious is the interaction between Eletriptan and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mental status change, hyperthermia, rigidity and autonomic instability. Discontinue the agents if features of either syndrome appear.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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