Drug interactions
Eletriptan + Trifluoperazine
Severity: Moderate
Eletriptan and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concomitant triptan and phenothiazine use may increase the risk of serotonin syndrome and, theoretically, neuroleptic malignant syndrome. The absolute risk is low but the outcomes can be serious.
What this interaction means in plain words
Eletriptan and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic and dopaminergic effects of the two agents.
What to do
Monitor for agitation, tremor, hyperthermia, rigidity and autonomic instability, especially after dose changes. Stop treatment and give supportive care if either syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Trifluoperazine?
MediHelp rates the interaction as moderate. Eletriptan and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concomitant triptan and phenothiazine use may increase the risk of serotonin syndrome and, theoretically, neuroleptic malignant syndrome. The absolute risk is low but the outcomes can be serious.
How serious is the interaction between Eletriptan and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia, rigidity and autonomic instability, especially after dose changes. Stop treatment and give supportive care if either syndrome is suspected.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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