Drug interactions
Eliglustat + Eribulin
Severity: Moderate
Eliglustat and Eribulin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat can prolong the PR, QRS and QT intervals at high exposures, and eribulin also prolongs the QT interval. Together they may increase arrhythmia risk.
What this interaction means in plain words
Eliglustat and Eribulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eliglustat belongs to Miscellaneous; Eribulin belongs to Oncology.
Why it happens
Additive pharmacodynamic effect on cardiac repolarization and conduction.
What to do
Obtain a baseline ECG and correct electrolytes. Monitor the ECG during treatment and consider alternatives in patients with existing conduction disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eribulin
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Eribulin?
MediHelp rates the interaction as moderate. Eliglustat and Eribulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat can prolong the PR, QRS and QT intervals at high exposures, and eribulin also prolongs the QT interval. Together they may increase arrhythmia risk.
How serious is the interaction between Eliglustat and Eribulin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolytes. Monitor the ECG during treatment and consider alternatives in patients with existing conduction disease.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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