Drug interactions
Eliglustat + Erythromycin
Severity: Major
Eliglustat and Erythromycin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4 and can markedly raise eliglustat levels, which in turn prolongs the PR, QRS and QT intervals in a concentration-dependent way. Erythromycin itself prolongs the QT interval, adding to the arrhythmia risk.
What this interaction means in plain words
Eliglustat and Erythromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eliglustat belongs to Miscellaneous; Erythromycin belongs to Anti Bacterial.
Why it happens
CYP3A4 inhibition raises eliglustat exposure, combined with additive QT prolongation.
What to do
Avoid in poor or intermediate CYP2D6 metabolizers. In extensive metabolizers, reduce eliglustat to once daily and monitor the ECG, or choose a non-interacting antibiotic.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Erythromycin?
MediHelp rates the interaction as major. Eliglustat and Erythromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erythromycin inhibits CYP3A4 and can markedly raise eliglustat levels, which in turn prolongs the PR, QRS and QT intervals in a concentration-dependent way. Erythromycin itself prolongs the QT interval, adding to the arrhythmia risk.
How serious is the interaction between Eliglustat and Erythromycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in poor or intermediate CYP2D6 metabolizers. In extensive metabolizers, reduce eliglustat to once daily and monitor the ECG, or choose a non-interacting antibiotic.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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