Drug interactions
Eliglustat + Fingolimod
Severity: Major
Eliglustat and Fingolimod: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat can prolong PR, QRS and QT intervals at high concentrations, and fingolimod slows heart rate and may affect QT. The combination may increase the risk of arrhythmia.
What this interaction means in plain words
Eliglustat and Fingolimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eliglustat belongs to Miscellaneous; Fingolimod belongs to Central Nervous System.
Why it happens
Additive cardiac conduction effects and QTc prolongation, with fingolimod-induced bradycardia.
What to do
Avoid the combination when possible. If used together, obtain a baseline ECG, monitor ECG and heart rate, and correct electrolyte disturbances.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Fingolimod?
MediHelp rates the interaction as major. Eliglustat and Fingolimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eliglustat can prolong PR, QRS and QT intervals at high concentrations, and fingolimod slows heart rate and may affect QT. The combination may increase the risk of arrhythmia.
How serious is the interaction between Eliglustat and Fingolimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible. If used together, obtain a baseline ECG, monitor ECG and heart rate, and correct electrolyte disturbances.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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