Drug interactions
Eliglustat + Glyburide-metformin
Severity: Minor
Eliglustat and Glyburide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits intestinal P-glycoprotein and may raise exposure to glyburide, which is a P-gp substrate. Higher glyburide levels could increase the likelihood of hypoglycemia, although the clinical effect is expected to be modest.
What this interaction means in plain words
Eliglustat and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eliglustat belongs to Miscellaneous; Glyburide-metformin belongs to Endocrine.
Why it happens
Eliglustat inhibits P-glycoprotein efflux, increasing absorption and plasma concentrations of glyburide.
What to do
Monitor blood glucose when eliglustat is started or stopped in a patient on glyburide-metformin. Reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Glyburide-metformin?
MediHelp rates the interaction as minor. Eliglustat and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eliglustat inhibits intestinal P-glycoprotein and may raise exposure to glyburide, which is a P-gp substrate. Higher glyburide levels could increase the likelihood of hypoglycemia, although the clinical effect is expected to be modest.
How serious is the interaction between Eliglustat and Glyburide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when eliglustat is started or stopped in a patient on glyburide-metformin. Reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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