Drug interactions
Eliglustat + Imipramine
Severity: Major
Eliglustat and Imipramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat is metabolized mainly by CYP2D6, and imipramine inhibits CYP2D6 weakly to moderately while it is also a substrate of it. Higher eliglustat levels raise the risk of PR, QRS, and QT prolongation, and both drugs have conduction effects.
What this interaction means in plain words
Eliglustat and Imipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eliglustat belongs to Miscellaneous; Imipramine belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by imipramine raises eliglustat exposure, with additive effects on cardiac conduction.
What to do
Avoid if possible; if used, reduce eliglustat dose as per labeling and monitor ECG. Consider an antidepressant with less CYP2D6 and conduction effect.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Imipramine?
MediHelp rates the interaction as major. Eliglustat and Imipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eliglustat is metabolized mainly by CYP2D6, and imipramine inhibits CYP2D6 weakly to moderately while it is also a substrate of it. Higher eliglustat levels raise the risk of PR, QRS, and QT prolongation, and both drugs have conduction effects.
How serious is the interaction between Eliglustat and Imipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if used, reduce eliglustat dose as per labeling and monitor ECG. Consider an antidepressant with less CYP2D6 and conduction effect.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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