Drug interactions
Eliglustat + Isoflurane
Severity: Moderate
Eliglustat and Isoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat can prolong the PR, QRS and QT intervals at high concentrations, and isoflurane has some QT-prolonging effect. Combined use may increase arrhythmia risk, mainly in patients with high eliglustat exposure.
What this interaction means in plain words
Eliglustat and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eliglustat belongs to Miscellaneous; Isoflurane belongs to Central Nervous System.
Why it happens
Additive cardiac conduction and QT interval prolongation.
What to do
Check ECG and electrolytes before anesthesia and correct abnormalities. Monitor the ECG continuously during the procedure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoflurane
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Isoflurane?
MediHelp rates the interaction as moderate. Eliglustat and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat can prolong the PR, QRS and QT intervals at high concentrations, and isoflurane has some QT-prolonging effect. Combined use may increase arrhythmia risk, mainly in patients with high eliglustat exposure.
How serious is the interaction between Eliglustat and Isoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes before anesthesia and correct abnormalities. Monitor the ECG continuously during the procedure.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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