Drug interactions
Eliglustat + Lidocaine
Severity: Moderate
Eliglustat and Lidocaine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat is metabolized mainly by CYP2D6 and CYP3A4. Lidocaine is a minor substrate and weak competitor rather than a clinically significant inhibitor, so a large rise in eliglustat exposure is not expected. Eliglustat itself can prolong PR, QRS and QT intervals, so antiarrhythmic use adds theoretical concern.
What this interaction means in plain words
Eliglustat and Lidocaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eliglustat belongs to Miscellaneous; Lidocaine belongs to Cardiovascular.
Why it happens
Possible weak competition for CYP2D6 metabolism plus additive cardiac conduction effects.
What to do
Monitor ECG when systemic lidocaine is given to patients on eliglustat. No adjustment is needed for local anesthetic use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Lidocaine?
MediHelp rates the interaction as moderate. Eliglustat and Lidocaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat is metabolized mainly by CYP2D6 and CYP3A4. Lidocaine is a minor substrate and weak competitor rather than a clinically significant inhibitor, so a large rise in eliglustat exposure is not expected. Eliglustat itself can prolong PR, QRS and QT intervals, so antiarrhythmic use adds theoretical concern.
How serious is the interaction between Eliglustat and Lidocaine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG when systemic lidocaine is given to patients on eliglustat. No adjustment is needed for local anesthetic use.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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