Drug interactions
Eliglustat + Lorlatinib
Severity: Major
Eliglustat and Lorlatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat is metabolized by CYP2D6 and CYP3A4, and lorlatinib may lower its exposure. This can lead to loss of efficacy in Gaucher disease.
What this interaction means in plain words
Eliglustat and Lorlatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eliglustat belongs to Miscellaneous; Lorlatinib belongs to Oncology.
Why it happens
Lorlatinib induces CYP3A4, increasing eliglustat metabolism.
What to do
Eliglustat labeling advises against use with strong CYP3A inducers, so choose an alternative or avoid the combination. If it cannot be avoided, monitor clinical response closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Lorlatinib?
MediHelp rates the interaction as major. Eliglustat and Lorlatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eliglustat is metabolized by CYP2D6 and CYP3A4, and lorlatinib may lower its exposure. This can lead to loss of efficacy in Gaucher disease.
How serious is the interaction between Eliglustat and Lorlatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Eliglustat labeling advises against use with strong CYP3A inducers, so choose an alternative or avoid the combination. If it cannot be avoided, monitor clinical response closely.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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