Drug interactions
Eliglustat + Methadone
Severity: Major
Eliglustat and Methadone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methadone is a CYP2D6 inhibitor and may raise eliglustat concentrations, and both drugs can prolong the QT interval. Higher eliglustat exposure increases the risk of cardiac conduction abnormalities and arrhythmia.
What this interaction means in plain words
Eliglustat and Methadone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eliglustat belongs to Miscellaneous; Methadone belongs to Musculoskeletal.
Why it happens
Methadone inhibition of CYP2D6 reduces eliglustat clearance, with additive QT effects.
What to do
Avoid if possible; if used, obtain an ECG and monitor QTc, and reduce eliglustat dose as labeled for CYP2D6 inhibitors. Do not add CYP3A inhibitors.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Methadone?
MediHelp rates the interaction as major. Eliglustat and Methadone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methadone is a CYP2D6 inhibitor and may raise eliglustat concentrations, and both drugs can prolong the QT interval. Higher eliglustat exposure increases the risk of cardiac conduction abnormalities and arrhythmia.
How serious is the interaction between Eliglustat and Methadone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if used, obtain an ECG and monitor QTc, and reduce eliglustat dose as labeled for CYP2D6 inhibitors. Do not add CYP3A inhibitors.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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