Drug interactions
Eliglustat + Nortriptyline
Severity: Major
Eliglustat and Nortriptyline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits CYP2D6, the main enzyme clearing nortriptyline, which can raise tricyclic concentrations. Both drugs can prolong the QT interval, so the combination increases the risk of arrhythmia.
What this interaction means in plain words
Eliglustat and Nortriptyline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eliglustat belongs to Miscellaneous; Nortriptyline belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by eliglustat raising nortriptyline levels, plus additive QT prolongation.
What to do
Monitor ECG and nortriptyline concentrations, and reduce the nortriptyline dose as needed. Consider an alternative antidepressant if QTc prolongs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Nortriptyline?
MediHelp rates the interaction as major. Eliglustat and Nortriptyline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eliglustat inhibits CYP2D6, the main enzyme clearing nortriptyline, which can raise tricyclic concentrations. Both drugs can prolong the QT interval, so the combination increases the risk of arrhythmia.
How serious is the interaction between Eliglustat and Nortriptyline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and nortriptyline concentrations, and reduce the nortriptyline dose as needed. Consider an alternative antidepressant if QTc prolongs.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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