Drug interactions
Eliglustat + Paroxetine
Severity: Major
Eliglustat and Paroxetine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paroxetine is a strong CYP2D6 inhibitor and markedly increases eliglustat concentrations. This can prolong PR, QRS and QT intervals and cause arrhythmia, particularly if a CYP3A inhibitor is also given.
What this interaction means in plain words
Eliglustat and Paroxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eliglustat belongs to Miscellaneous; Paroxetine belongs to Central Nervous System.
Why it happens
Paroxetine strongly inhibits CYP2D6, the main pathway for eliglustat clearance.
What to do
Reduce eliglustat dose per labeling and monitor ECG. Do not use if a CYP3A inhibitor is also being taken, and avoid in CYP2D6 poor metabolisers.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Paroxetine?
MediHelp rates the interaction as major. Eliglustat and Paroxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Paroxetine is a strong CYP2D6 inhibitor and markedly increases eliglustat concentrations. This can prolong PR, QRS and QT intervals and cause arrhythmia, particularly if a CYP3A inhibitor is also given.
How serious is the interaction between Eliglustat and Paroxetine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce eliglustat dose per labeling and monitor ECG. Do not use if a CYP3A inhibitor is also being taken, and avoid in CYP2D6 poor metabolisers.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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