Drug interactions
Eliglustat + Sunitinib
Severity: Moderate
Eliglustat and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both sunitinib and eliglustat can lengthen the QT interval, and eliglustat at high concentrations prolongs PR, QRS and QT intervals. Together they may increase the likelihood of ventricular arrhythmias, particularly in patients with cardiac disease or electrolyte imbalance.
What this interaction means in plain words
Eliglustat and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eliglustat belongs to Miscellaneous; Sunitinib belongs to Oncology.
Why it happens
Additive pharmacodynamic prolongation of cardiac repolarization.
What to do
Check a baseline ECG and monitor QTc during co-therapy, correcting potassium and magnesium. Avoid in patients with congenital long QT or significant heart disease where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Sunitinib?
MediHelp rates the interaction as moderate. Eliglustat and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both sunitinib and eliglustat can lengthen the QT interval, and eliglustat at high concentrations prolongs PR, QRS and QT intervals. Together they may increase the likelihood of ventricular arrhythmias, particularly in patients with cardiac disease or electrolyte imbalance.
How serious is the interaction between Eliglustat and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and monitor QTc during co-therapy, correcting potassium and magnesium. Avoid in patients with congenital long QT or significant heart disease where possible.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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