Drug interactions
Eliglustat + Tamoxifen
Severity: Major
Eliglustat and Tamoxifen: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat is a CYP2D6 inhibitor and may reduce conversion of tamoxifen to endoxifen, its most potent active metabolite. This could diminish tamoxifen efficacy, even though parent drug levels may rise.
What this interaction means in plain words
Eliglustat and Tamoxifen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eliglustat belongs to Miscellaneous; Tamoxifen belongs to Endocrine.
Why it happens
CYP2D6 inhibition by eliglustat reduces endoxifen formation from tamoxifen.
What to do
Avoid the combination where possible, or consider an alternative therapy for Gaucher disease or an aromatase inhibitor in eligible patients.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tamoxifen
- Amiodarone + Tamoxifen Major
- Anastrozole + Tamoxifen Major
- Bupropion + Tamoxifen Major
- Carbamazepine + Tamoxifen Major
- Cinacalcet + Tamoxifen Major
- Dacomitinib + Tamoxifen Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Tamoxifen?
MediHelp rates the interaction as major. Eliglustat and Tamoxifen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eliglustat is a CYP2D6 inhibitor and may reduce conversion of tamoxifen to endoxifen, its most potent active metabolite. This could diminish tamoxifen efficacy, even though parent drug levels may rise.
How serious is the interaction between Eliglustat and Tamoxifen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or consider an alternative therapy for Gaucher disease or an aromatase inhibitor in eligible patients.
What other medicines interact with Tamoxifen?
MediHelp also lists interactions of Tamoxifen with, for example, Amiodarone, Anastrozole, Bupropion. The full list is on the Tamoxifen page.
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