Drug interactions
Eliglustat + Timolol
Severity: Moderate
Eliglustat and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits CYP2D6, the main enzyme metabolizing timolol. Plasma timolol may rise, increasing risks of bradycardia and hypotension. Eliglustat labeling cautions about CYP2D6 substrates such as beta blockers.
What this interaction means in plain words
Eliglustat and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eliglustat belongs to Miscellaneous; Timolol belongs to Cardiovascular.
Why it happens
Eliglustat inhibits CYP2D6-mediated metabolism of timolol.
What to do
Monitor heart rate and blood pressure and consider reducing the timolol dose. Ophthalmic timolol carries lower but nonzero risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Timolol?
MediHelp rates the interaction as moderate. Eliglustat and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat inhibits CYP2D6, the main enzyme metabolizing timolol. Plasma timolol may rise, increasing risks of bradycardia and hypotension. Eliglustat labeling cautions about CYP2D6 substrates such as beta blockers.
How serious is the interaction between Eliglustat and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and consider reducing the timolol dose. Ophthalmic timolol carries lower but nonzero risk.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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