Drug interactions
Eliglustat + Tolterodine
Severity: Moderate
Eliglustat and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits CYP2D6, the main route of tolterodine conversion to its active metabolite, so tolterodine levels may rise. CYP3A4 provides an alternative pathway, which limits the effect, but anticholinergic effects and QT prolongation may increase.
What this interaction means in plain words
Eliglustat and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eliglustat belongs to Miscellaneous; Tolterodine belongs to Genitourinary.
Why it happens
Inhibition of CYP2D6-mediated tolterodine metabolism by eliglustat, and both drugs can prolong QT.
What to do
Monitor for anticholinergic adverse effects and consider limiting the tolterodine dose, with ECG monitoring in patients with QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Tolterodine?
MediHelp rates the interaction as moderate. Eliglustat and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat inhibits CYP2D6, the main route of tolterodine conversion to its active metabolite, so tolterodine levels may rise. CYP3A4 provides an alternative pathway, which limits the effect, but anticholinergic effects and QT prolongation may increase.
How serious is the interaction between Eliglustat and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and consider limiting the tolterodine dose, with ECG monitoring in patients with QT risk factors.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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