Drug interactions
Eliglustat + Tolvaptan
Severity: Moderate
Eliglustat and Tolvaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits P-glycoprotein and may raise tolvaptan exposure, increasing thirst, polyuria and the risk of excessive aquaresis, dehydration and overly rapid sodium correction. The size of the effect has not been well characterized.
What this interaction means in plain words
Eliglustat and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eliglustat belongs to Miscellaneous; Tolvaptan belongs to Endocrine.
Why it happens
Inhibition of intestinal and renal P-glycoprotein efflux reduces tolvaptan clearance.
What to do
Monitor serum sodium and fluid status closely, and consider a lower tolvaptan dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Tolvaptan?
MediHelp rates the interaction as moderate. Eliglustat and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat inhibits P-glycoprotein and may raise tolvaptan exposure, increasing thirst, polyuria and the risk of excessive aquaresis, dehydration and overly rapid sodium correction. The size of the effect has not been well characterized.
How serious is the interaction between Eliglustat and Tolvaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium and fluid status closely, and consider a lower tolvaptan dose if adverse effects occur.
What other medicines interact with Tolvaptan?
MediHelp also lists interactions of Tolvaptan with, for example, Atazanavir, Ceritinib, Cobicistat. The full list is on the Tolvaptan page.
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