Drug interactions
Elranatamab + Pirfenidone
Severity: Moderate
Elranatamab and Pirfenidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytokine release syndrome from elranatamab can suppress CYP enzyme activity and increase exposure to CYP1A2 substrates such as pirfenidone. This may increase pirfenidone adverse effects like nausea, photosensitivity and liver enzyme elevation, mainly during step-up dosing and CRS.
What this interaction means in plain words
Elranatamab and Pirfenidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elranatamab belongs to Oncology; Pirfenidone belongs to Miscellaneous.
Why it happens
Cytokine-mediated suppression of CYP1A2 activity reduces pirfenidone clearance.
What to do
Monitor for pirfenidone toxicity and liver enzymes during elranatamab initiation and any CRS episode. Consider temporary pirfenidone dose reduction if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pirfenidone
Other interactions of Elranatamab
- Elranatamab + Ergotamine Major
- Elranatamab + Pimozide Major
- Bendamustine + Elranatamab Moderate
- Carbamazepine + Elranatamab Moderate
- Clomipramine + Elranatamab Moderate
- Clozapine + Elranatamab Moderate
Frequently asked questions
Can I take Elranatamab with Pirfenidone?
MediHelp rates the interaction as moderate. Elranatamab and Pirfenidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cytokine release syndrome from elranatamab can suppress CYP enzyme activity and increase exposure to CYP1A2 substrates such as pirfenidone. This may increase pirfenidone adverse effects like nausea, photosensitivity and liver enzyme elevation, mainly during step-up dosing and CRS.
How serious is the interaction between Elranatamab and Pirfenidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for pirfenidone toxicity and liver enzymes during elranatamab initiation and any CRS episode. Consider temporary pirfenidone dose reduction if adverse effects emerge.
What other medicines interact with Pirfenidone?
MediHelp also lists interactions of Pirfenidone with, for example, Carbamazepine, Ciprofloxacin, Fluvoxamine. The full list is on the Pirfenidone page.
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